ASD - ALTERNATIVE SPLICING


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FIELD NAME
FIELD VALUE
  
AEdbMotif ID:321
Internal ref. ID:605-2004
Submitter name:FEDERICO MARIA ROSSI
Entry date:01-SEP-2005 15:38:27
Modification date:01-SEP-2005 15:43:53
 
Regulatory sequence name:purine-rich ese
Entry type:Exon enhancer
Sequence origin:Exonic
Organism:Homo sapiens, human
Binding factors:SF2/ASF, SC35
 
EMBL/Genbank/DDBJ/RefSeq Accession number:X04898
Ensembl ID:ENSG00000158874
AEdb ID:
Sequence:TGATGGAGA
Mutated regulatory sequence:
 
Methods:Deletion analysis
Keywords:apoa-ii,apolipoprotein a-ii,atypical 3’ splice site,(gu)16 polypyrimidine tract,exon 3 ese
 
Citation line:Arrisi-Mercado P, Romano M, Muro AF, Baralle FE. “An exonic splicing enhancer offsets the atypical GU-rich 3' splice site of human apolipoprotein A-II exon 3.” J Biol Chem. 2004 Sep 17;279(38):39331-9. Epub 2004 Jul 7.
PubMed ID:15247216
 
Comments:This enhancer allows the atypical (GU)16 polypyrimidine tract (in 3’ site of apoA-II intron 2) to be used as a splice site for apoA-II exon 3, which otherwise could not bind U2AF65. Mutated regulatory sequences: AGATGGAGA;TCATGGAGA;TGTTGGAGA;TGAAGGAGA;TGATCGAGA;TGATGCAGA;TGATGGTGA;TGATGGACA;TGATGGAGT
(activated in workbench):N
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