Aznarez, I., E. M. Chan, J. Zielenski, B. J. Blencowe, and L. C. Tsui. 2003., Characterization of disease-associated mutations affecting an exonic splicing enhancer and two cryptic splice sites in exon 13 of the cystic fibrosis transmembrane conductance regulator gene. Hum.Mol.Genet. 12:2031-2040.
Increased expression of TRA2A decreased the aberrant splicing of exon 13 caused by two exonic splicing mutations, E656X and 2108delA. SFRS1 exacerbated the effect of D651N, E664X and T665S mutations on the splicing of exon 13. That opposite effects were observed for SFRS1 and TRA2A argues that their effects are specific and not a general consequence of over-expression of splicing factors