ASD - ALTERNATIVE SPLICING


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FIELD NAME
FIELD VALUE
  
AEdbMotif ID:218
Internal ref. ID:
Submitter name:DARYA, STEFAN
Entry date:27-SEP-2004 19:26:42
Modification date:20-SEP-2005 15:18:38
 
Regulatory sequence name:alpha-tropomyosin, intron2
Entry type:Intron silencer
Sequence origin:Intronic
Organism:Rattus sp., rat
Binding factors:
 
EMBL/Genbank/DDBJ/RefSeq Accession number:
Ensembl ID:ENSRNOG00000018184
AEdb ID:
Sequence:ATCACGCTGCCTGCTGCA
Mutated regulatory sequence:
 
Methods:Unknown
Keywords:
 
Citation line:Gooding, C, Roberts, G, Moreau, G, Nadal-Ginard, B and Smith, C: Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J 1994, 13:3861-3872.Pérez, I, Lin, C-H, McAfee, J and Patton, J: Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo. RNA 1997, 3:764-778.Gooding, C, Roberts, G and Smith, C: Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated a-tropomyosin exon. RNA 1998, 4:85-100.
PubMed ID:8070413 , 9214659 , 9436911
 
Comments:The 5' part of the upstream of exon 3 (position: -75 to -1) was shown to be most essential, the downstream sequence may have secondary effects.
(activated in workbench):Y
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