ASD - ALTERNATIVE SPLICING


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FIELD NAME
FIELD VALUE
  
AEdbMotif ID:108
Internal ref. ID:1149b
Submitter name:DARYA
Entry date:21-SEP-2004 10:20:57
Modification date:19-SEP-2005 14:04:22
 
Regulatory sequence name:calca: calcitonin/calcitonin-related polypeptide, alpha, exon 4
Entry type:Exon enhancer
Sequence origin:Exonic
Organism:Rattus sp., rat
Binding factors:hTra2 , SRp55
 
EMBL/Genbank/DDBJ/RefSeq Accession number:NM_017338
Ensembl ID:ENSRNOG00000011130
AEdb ID:
Sequence:AAGAAAAGGGA
Mutated regulatory sequence:
 
Methods:Deletion analysis
UV cross-linking
Keywords:calcitonin gene-related peptide,hela cells,nerve tissue proteins,nuclear proteins,thyroid gland,calca: calcitonin/calcitonin-related polypeptide,alpha,exon 4
 
Citation line:Tran, Q., T. P. Coleman, et al. (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer." Biochim Biophys Acta 1625(2): 141-52
PubMed ID:12531473
 
Comments:The calcitonin/calcitonin gene-related peptide (CGRP) pre-mRNA is alternatively processed in a tissue-specific manner leading to the production of calcitonin mRNA in thyroid C cells and CGRP mRNA in neurons. Sequences in the human calcitonin-specific fourth exon function as an exonic splice enhancer (ESE) which is required for incorporation of exon 4 into calcitonin mRNA.
(activated in workbench):Y
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